MOTS-C

{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"MOTS-C is a 16-amino-acid peptide with the sequence "},{"type":"text","value":"MRWQEMGYIFYPRKLR","bold":true},{"type":"text","value":". Unusually, it is encoded in mitochondrial DNA rather than in the cell nucleus — one of a small group of peptides known to originate there. Harbor supplies it as a lyophilized powder for laboratory research."}]}]}

{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Almost every peptide studied in the lab is transcribed from nuclear DNA. MOTS-C is read from a short open reading frame inside the mitochondrial 12S rRNA gene (MT-RNR1) — a region long assumed not to code for peptides at all. That origin is what makes it a distinct class of research material rather than a variation on a familiar one."}]}]}

{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"No. MOTS-C is not an approved drug, a dietary supplement, a cosmetic or a food additive, and it has not been evaluated by the FDA for any purpose."}]},{"type":"paragraph","children":[{"type":"text","value":"It is sold strictly as a research chemical and is "},{"type":"text","value":"not for human or veterinary use","bold":true},{"type":"text","value":"."}]}]}

{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Every lot is analysed by Freedom Diagnostics, an independent laboratory in the United States — HPLC-UV for purity and LC-MS for identity."}]},{"type":"paragraph","children":[{"type":"text","value":"The certificate for the exact lot you receive is published on this page. The analysis summary above shows the measured purity and net content, and the certificate carries a search code you can use to verify the result directly with the laboratory rather than taking our word for it."}]}]}

{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"It ships as a lyophilized powder. For laboratory work it is normally brought into solution with bacteriostatic water, added slowly down the inside wall of the vial rather than directly onto the powder, then left to dissolve without shaking."}]},{"type":"paragraph","children":[{"type":"text","value":"The volume used depends on the working concentration your protocol calls for."}]}]}

{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Sealed vials are held at −20°C and protected from light."}]},{"type":"paragraph","children":[{"type":"text","value":"Once in solution, keep refrigerated and use within the window appropriate to your protocol. Repeated freeze–thaw cycles should be avoided."}]}]}